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October 16-20, 2010 San Diego, CA Home Abstract Archive Search Abstracts 2010 Session Grid 2010 Meeting Website Policy Statements ASA Website Feedback 
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A1643
October 16, 2007 1:30 PM - 3:00 PM Room Room 301 |
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| Oscillations of the Arterial Partial Oxygen Pressure in Different Animal Models of Lung Injury | ||||||||||||||||||||||||||||||||
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Marc Bodenstein, M.D., Stefan Boehme, Jens Karmrodt, M.D., Matthias David, M.D., Klaus Markstaller, M.D., P.D. Dept. of Anesthesiology, Johannes Gutenberg-University, Mainz, Germany |
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Introduction This study aims to describe cyclic recruitment of atelectasis in two porcine models of acute lung injury (ALI) by ultrafast arterial pO2 (PaO2) measurements. Methods With IRB approval, 30 pigs were anesthetized and ventilated by pressure controlled ventilation (FIO2 = 1.0, respiratory rate 8/min, VT variable to allow normocapnia). Arterial and venous catheterization was performed by surgical cut-down of central vessels. Animals were randomized to sham operation (Sham, n = 10), wash out of surfactant (LAV, n = 10), or intravenous infusion of oleic acid (OAI, n = 10). Oscillations of the arterial pO2 were measured in the thoracic aorta by a fluorescent quenching technique (Foxxy probe, Ocean Optics, Florida, USA, temporal resolution = 4 Hz). Measurements were recorded at baseline and two and five hours after ALI induction. Simultaneously, mean PaO2 values were assessed by conventional blood gas analysis. Statistical analysis was performed by ANOVA on ranks and T-test. Results The amplitude of PaO2 oscillations and the average PaO2 are shown in table 1. Conclusion As expected, mean PaO2 decreased significantly in animals after ARDS induction compared to sham animals. Oscillations of the PaO2 were observed in all groups. Although this phenomenon was evident in all groups, the range of paO2 oscillations was higher after induction of lung injury. Thus, oscillations in the arterial pO2 are likely to reflect cyclic recruitment and de-recruitment in damaged lungs. Funding: German Research Foundation (DFG-FOR 474/3).[table1] Anesthesiology 2007; 107: A1643 |
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