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Hemispheric Synchronized Sounds and Perioperative Analgesic Requirements |
Susan M. Dabu-Bondoc, M.D., Nalini Vadivelu, M.D., Megan Weinberg, M.A., Jill E. MacLaren, Ph.D., Zeev N. Kain, M.D., M.B.A. Anesthesiology, Yale University School of Medicine, New Haven, Connecticut |
The use of hemispheric synchronized (Hemi-Sync) sounds in the operating room has been promoted to decrease anxiety, perioperative anesthetic or analgesic consumption but data is limited. 60 ambulatory patients were consented and randomized into 3 groups: treatment group had hemisync sounds (n=20), music group had music tapes of their choice (n=20), and control (placebo) group had a blank cassette tape (n=20). The intervention was applied in the preoperative area and during the surgical procedure. After a propofol-nitrous-vecuronium general anesthesia perioperative analgesic requirements were recorded. To ensure uniformity of hypnotic depth in all participants a bispectral index monitor was used. The Hemi-Sync group had a significantly reduced intraoperative analgesic consumption compared to the music (p=0.02) and control group (p = 0.04). Although pain (VAS) scores were significantly less in the Hemi-Sync group 1 hour and 24 hours after surgery, analgesic requirements were similar among the three groups throughout the 24 hour postoperative period. Time to discharge trended lower in participants who had Hemi-Sync (p=.058); incidence of nausea/vomiting, oxygen desaturation. patient recall, and patient satisfaction were similar in all groups. We conclude that the use Hemi-Sync sounds before and during general anesthesia decreases intraoperative but not postoperative analgesic requirements.[table1][table2] Anesthesiology 2008; 109 A1267 |
[table 1] Baseline Characteristics| Variable | HemiSync group | Music group | Control group | P value | | Age (yr) | 42.3 +/- 13.8 | 41.2 +/- 13.1 | 41.1 +/- 10.5 | 0.94 | | Education (yr) | 15.5 +/- 03.0 | 13.9 +/- 02.5 | 14.9 +/- 03.0 | 0.19 | | Sex (% male; % female) | 38/62 | 45/55 | 28/72 | 0.55 | | State anxiety (STAI) | 40.0 +/- 13.0 | 42.2 +/- 11.6 | 43.4 +/- 10.7 | 0.65 | | Trait anxiety (STAI) | 34.8 +/- 09.0 | 40.6 +/- 11.4 | 39.8 +/- 08.2 | 0.13 | | Prior surgery (%) | 25/75 | 24/76 | 39/61 | 0.53 | | Weight (kg) | 74.6 +/- 14.9 | 76.7 +/- 17.8 | 74.1 +/- 18.0 | 0.88 | Continuous data were analyzed by one way ANOVA, categorical data by chi-square test |
[table 2] Results| Variable | Hemisync group | Music group | Control group | P value | | Intraop Fentanyl * | 14.6 +/- 6.9 | 20.9 +/- 9.1 | 20.3 +/- 9.4 | 0.046 | | Postop (PACU) analgesic** | 15.0 +/ 12.9 | 14.4 +/-13.2 | 16.9 +/- 12.8 | 0.830 | | Postop (Home) analgesic** | 18.6 +/-11.6 | 28.0 +/-16.4 | 25.0 +/- 13.1 | 0.099 | | Total periop analgesic | 48.3+/- 21.8 | 62.6+/- 29.1 | 61.7+/- 24.0 | 0.144 | | VAS score T0 in PACU | 3.8 +/- 3.4 | 4.5 +/- 3.3 | 5.4 +/- 2.5 | 0.300 | | VAS score T10 in PACU | 4.0 +/- 3.3 | 3.8 +/- 2.7 | 5.2 +/- 2.3 | 0.258 | | VAS Score T20 in PACU | 3.6 +/- 2.8 | 4.5 +/- 2.4 | 4.3 +/- 2.2 | 0.520 | | VAS Score T30 in PACU | 3.5 +/- 2.0 | 3.4 +/- 1.4 | 4.1 +/- 2.4 | 0.541 | | VAS score T60 in PACU | 2.6 +/- 1.6 | 4.2 +/- 2.1 | 3.9 +/- 1.7 | 0.020 | | VAS score 24 hrs postop | 3.5 +/- 1.5 | 5.3 +/- 1.8 | 5.0 +/- 2.0 | 0.005 | | Discharge time | 120.2 +/-37.3 | 156.6 +/-65.6 | 162.8 +/-68.2 | 0.058 | | PONV | 0.1 +/- 0.5 | 0.2 +/- 0.4 | 0.2 +/- 0.4 | 0.608 | | Recall | 0 | 0 | 0 | N/A | | Patient satisfaction | 3.9 +/- 0.2 | 4.0 +/- 0.2 | 3.9 +/- 0.4 | 0.124 | | Total propofol (mcg/min/kg)*** | 0.18 +/- 0.06 | 0.17 +/- 0.04 | 0.20 +/- 0.13 | 0.43 | *fentanyl requirements in mcg converted to IV morphine mg equivalents |