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October 21, 2008
9:00 AM - 11:00 AM
Room Hall E2-Area A,
The Effect of Nitious Oxide on Intracuff Pressure of ProsealTM Laryngeal Mask Airway.
Benzhen Chen, M.D., Lihui Luo, M.D., Ling Tan, M.D.
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Background: The ProSealTM laryngeal mask airway (PLMA) is a new laryngeal mask airway with a modified cuff designed to improve its seal and a drain tube for gastric tube placement. The cuff of ProSealTM laryngeal mask airway is made from silicone-based rubber,a material that rapidly absorbs nitrous oxide (N2O) and volatile anesthetic agents. The purpose of this study was to investigate intracuff pressure changes found in ProSealTM laryngeal mask airway during 50% nitrous oxide anesthesia.

Methods: Forty children of ASA physical statusI-II, aged 2-6 years, weighed 10-20kg, scheduled for elective sub-umbillical surgery were randomized divided to two groups. Paitents were placed ProsealTM laryngeal mask airway under general anesthesia. The cuffs were filled with air, the cuff pressures starting from a baseline pressure of 30 mmHg were monitored using a pressure transducer for 30 min. In group A , a sustained 50% nitrous oxide in oxygen was inhaled.In group B, a sustained 50% air in oxygen was inhaled. The cuff pressure was recorded every 3 minutes and the occurrence of children's postoperative throat discomfort was record.ANOVA was used for the analysis of intracuff pressure.

Result: The intracuff pressure changes of the two group were shown in.[figure1]In group A, when inhaled 50% nitrous oxide for 30 min, the intracuff pressure reached 86.7±10.4 mmHg, significantly higher than that of group B (29.7 ± 1.0mmHg).The postoperative throat complication rate in group A was 45%,which was significantly higher than that in group B(5%).

Conclusion: The intracuff pressure of ProSealTM laryngeal mask airway increased significantly during 50% nitrous oxide anesthesia. Postoperative throat complication rate of the children was increased, too.

Anesthesiology 2008; 109 A1268
Figure 1