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October 16-20, 2010 San Diego, CA Home Abstract Archive Search Abstracts 2010 Session Grid 2010 Meeting Website Policy Statements ASA Website Feedback 
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A1137
October 20, 2008 2:00 PM - 4:00 PM Room Hall E2-Area N, |
| Concentrations of Remifentanil to Prevent Tracheal Iutubation Response Anesthetized with Etomidate |
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Xiaoming Deng, M.D. Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China |
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Objectlve To determine the effective target plasma concentrations required to prevent tracheal intubation response in 50% of patients(Cp50) anesthetized with different doses of etomidate. Methods Sixty ASA I or II patients aged 18-55 year with body mass index between 20-30kg/m2 undergoing elective general anesthesia were enrolled in the study. BP, HR and ECG were continuously monitored and recorded before intubation (baseline) and at 1 and 2 min after intubation. Patients were randomly divided into 3 groups (E0.2,E0.3,E0.4, n=20 each) according to the doses of etomidate during induction of anesthesia: 0.2, 0.3 and 0.4mg/kg. Intubation response was defined as an increase in SBP and/or HR by 15% of the baseline value within 2min. Remifentanil was administered by TCI at a plasma concentration of 6 µg/L for 5 min followed by intravenous different doses of etomidate given within 30 seconds. When the patients lost consciousness, intravenous rocuronium 0.6mg/kg was given to facilitate tracheal intubation which was accomplished within 30 seconds. Cp50 was determined by up and down sequential trial. The ratio of two consecutive target plasma concentration was 1.2. Results The Cp50 of remifentanil in E0.2, E0.3, E0.4 group were respectively 4.23, 3.37 and 2.79µg·L-1. The 95% confidence intervals were respectivelly 3.94-4.53µg/L, 3.02-3.75µg/L and 2.69-2.90µg/L. Conclusion The Cp50 of remifentanil for suppression of cardiovascular response to tracheal intubation were 4.23, 3.37 and 2.79µg·L-1 in patients anesthetized with 0.2,0.3 and 0.4mg/kg etomidate respectively. Anesthesiology 2008; 109 A1137 |