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A4039
October 16, 2018
10/16/2018 10:30:00 AM - 10/16/2018 12:30:00 PM
Room North, Hall D, Area E
Use of Sugammadex Significantly Reduces the Likelihoods of Having Bradycardia and Nausea/vomiting After General Anesthesia in Adults: A Meta-analysis
Kuo-Ching Lu, M.B.,B.Ch., Yu-Ting Tai, M.D., Chun-Jen Huang, M.D.,Ph.D.
Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Disclosures: K. Lu: None. Y. Tai: None. C. Huang: None.
Abstract: Introduction: The efficacy of sugammadex for reversal of neuromuscular blocking effects of rocuronium bromide has been established. Sugammadex lacks of cholinergic effects. By substituting the cholinesterase inhibitors (e.g., neostigmine) with sugammadex, theoretically one would expect to avoid or minimize the post-operative adverse effects related to the cholinergic side effects of the cholinesterase inhibitors, such as bradycardia and post-operative nausea and vomiting (PONV). Herein, we conducted this meta-analysis study to elucidate further on this issue. Our hypothesis was that the likelihoods of having bradycardia and PONV in subjects using sugammadex were significantly lower than those in subjects using neostigmine after general anesthesia in adults. . Methods: A comprehensive search was conducted using PubMed, Embase and Cochrane Library electronic databases to identify relevant randomized controlled trials (RCTs). Only RCTs published in English were included. Two reviewers independently screened the trials and extracted data on the incidences of bradycardia and PONV after general anesthesia in adults according to the detailed guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. Results: A total of 15 RCTs with a total of 1427 subjects were included. Our data revealed that subjects using sugammadex were associated with significantly lower likelihoods of having post-operative bradycardia (OR=0.14; 95% CI=0.07-0.32; P<0.00001, I2=0%) and PONV (OR=0.67; 95% CI=0.48-0.93; P=0.02, I2=19%) compared to those of subjects using neostigmine. Conclusions: This meta-analysis study confirmed that use of sugammadex significantly reduce the likelihoods of having post-operative bradycardia and PONV after general anesthesia in adults.

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